100-1008 Horace Wilkinson Bridge southeast

The Horace Wilkinson Bridge is a cantilever bridge carrying Interstate 10 in Louisiana across the Mississippi River from Port Allen in West Baton Rouge Parish to Baton Rouge in East Baton Rouge Parish. Around the Baton Rouge Metropolitan Area, the bridge is more commonly known as the "New Bridge" because it is the younger of the two bridges that cross the river in Baton Rouge. The structure begins at the Louisiana Highway 1 (LA 1) exit south of Port Allen. After the interstate crosses the superstructure, it remains an elevated viaduct up to the Dalrymple Drive exit to Louisiana State University. It is the highest bridge on the Mississippi River.

The bridge is named after three separate Horace Wilkinsons who served a total of 54 years in the Louisiana legislature. Horace Wilkinson, along with his son and grandson, were honored with the naming of the I-10 bridge by Act 206 of the Louisiana Legislature in 1968.

Locally it is notorious for daily traffic snags for several reasons. Eastbound congestion occurs when congestion, created upstream, stretches through the I-10/I-110 junction, persists since I-10 narrows to just one lane at the I-110 South merge. This congestion is not helped by local traffic from I-110 South exiting at Washington Street crossing the only lane of I-10. Westbound congestion occurs from slower traffic entering from the short transition zone of the St. Ferdinand Street entrance ramp and the narrowing of I-10 when it loses a lane to exit at LA 1. Around October 2003, the I-10E/I-110S merge was restriped to reduce I-110 South from three lanes to two lanes, allowing I-10 its own lane, no longer mandating I-10 East commuters to shift to the left to continue on I-10 East.