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The Trail of Tears is a name given to the forced relocation and movement of Native American nations from southeastern parts of the United States following the Indian Removal Act of 1830. The removal included many members of the Cherokee, Muscogee (Creek), Seminole, Chickasaw, and Choctaw nations, among others in the United States, from their homelands to Indian Territory (eastern sections of the present-day state of Oklahoma). The phrase originated from a description of the removal of the Choctaw Nation in 1831. Many Native Americans suffered from exposure, disease and starvation en route to their destinations. Many died, including 4,000 of the 15,000 relocated Cherokee.

In 1831, the Cherokee, Chickasaw, Choctaw, Muscogee-Creek, and Seminole (sometimes collectively referred to as the Five Civilized Tribes) were living as autonomous nations in what would be called the American Deep South. The process of cultural transformation (proposed by George Washington and Henry Knox) was gaining momentum, especially among the Cherokee and Choctaw. Andrew Jackson continued and renewed the political and military effort for the removal of the Native Americans from these lands with the passage of the Indian Removal Act of 1830.