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Cafayate is a town located at the central zone of the Valles Calchaquíes in the province of Salta, Argentina. It sits 1,683 metres (5,522 ft) above mean sea level, at a distance of 1,329 kilometres (826 mi) from Buenos Aires, 227 kilometres (141 mi) from Tucumán, 311 kilometres (193 mi) from Jujuy and 365 kilometres (227 mi) from Catamarca. It has about 12,000 inhabitants (2001 census [INDEC]).

The town is an important tourist centre for exploring the Calchaquíes valleys, and because of the quality and originality of the wines produced in the area. The largest golf course in South America, at 240 acres (0.97 km²), is currently being developed just outside of the city center at La Estancia de Cafayate. The town was founded in 1840 by Manuel Fernando de Aramburu, at the site of a mission. In 1863 the Cafayate Department was created, of which Cafayate is the capital.

The Calchaquí Valley (Spanish: Valles Calchaquíes) is an area in the northwestern region of Argentina which crosses the provinces of Catamarca, Tucumán and Salta. It is best known for its contrast of colours and its unique geography that ranges from the mountain desert to the subtropical forest.

There are a number of valleys and rivers within the Calchaquí Valley that have their own name, such as the Quebrada del Toro (Gorge of the Bull), Valle de Lerma (Lerma Valley) near Salta city, the Quebrada de Escoipe formed by the Escoipe River, the Valle Encantado at the feet of the Cuesta del Obispo, the Quebrada de las Conchas of the Conchas River near Cafayate, the valley of the Santa María River, and the Calchaquí River itself.

These valleys were once inhabited by a number of tribes. Ruins of the Quilmes can be found in Tucumán. Other tribes of the area included the Calchaquíes, Tafí, and the Yokavil (Santa María). Decades before facing the invasion of the Spanish colonization, the natives of these lands suffered the invasion of the Inca Empire.