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Argonne's Midwest Center for Structural Genomics deposits 1,000th protein structure

photo by Argonne National Laboratory on Flickr

Argonne's Midwest Center for Structural Genomics deposits 1,000th protein structure — Fotopedia
Friday, July 17, 2009---Andrzej Joachimiak and colleagues at Argonne's Midwest Center for Structural Genomics deposited the consortium's 1,000th protein structure into the Protein Data Bank.

This structure represents a dehydrogenase enzyme from the bacteria Colwellia psychrerythraea. The enzyme is capable of generating harmful reactive oxygen species and has been implicated in neurodegeneration, ischemia-reperfusion, cancer and several other disorders.

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Protein

Proteins (/ˈprˌtnz/ or /ˈprti.ɨnz/) are large biological molecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within living organisms, including catalyzing metabolic reactions, replicating DNA, responding to stimuli, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in folding of the protein into a specific three-dimensional structure that determines its activity.


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