Antioquia (Spanish pronunciation: [anˈtjokja]) is one of the 32 departments of Colombia, located in the central northwestern part of Colombia with a narrow section that borders the Caribbean Sea. Most of its territory is mountainous with some valleys, much of which is part of the Andes mountain range. Antioquia has been part of many territorial divisions of former countries created over the present day territory of Colombia, and prior to the Colombian Constitution of 1886, Antioquia State was a sovereign government in their own right.

The department covers an area of 63,612 km² (24,427 sq mi), and has a population of 5,819,358 (2006 estimate); 6,6 million (2010 estimate). Antioquia borders with the Córdoba Department and the Caribbean Sea to the north, Chocó to the west, to the east it borders the departments of Bolivar, Santander and Boyaca, and to the south the departments of Caldas and Risaralda.

Medellín is Antioquia's capital city, and the second largest city in the country. Other important towns are Santa Fe de Antioquia, the old capital located on the Cauca, and Puerto Berrío on the Magdalena.