The II Antofagasta Region (Spanish: II Región de Antofagasta) is one of Chile's fifteen first-order administrative divisions. It comprises three provinces, Antofagasta, El Loa and Tocopilla. It is bordered to the north by Tarapacá and by Atacama to the south and is the second-largest region of Chile.

The capital of the region is the port city of Antofagasta, another important city is Calama.