Apollodorus of Damascus was a Greek engineer from Syria, architect, designer and sculptor who flourished during the 2nd century AD, from Damascus, Roman Syria. He was a favourite of Trajan, for whom he constructed Trajan's Bridge over the Danube for the 105-106 campaign in Dacia.

He also designed the Forum Trajanum and Trajan's Column within the city of Rome, beside several smaller projects. Apollodorus also designed the triumphal arches of Trajan at Beneventum and Ancona. He is also widely credited as the architect of the Pantheon, and cited as the builder of the Alconétar Bridge in Spain. In 106 he also completed or restored the odeon begun in the Campus Martius under Domitian.

Trajan's Column, in the centre of the Forum, is celebrated as being the first triumphal monument of its kind. On the accession of Hadrian, whom he had offended by ridiculing his performances as architect and artist, Apollodorus was banished and, shortly afterwards, being charged with imaginary crimes, put to death. He also wrote a treatise on Siege Engines (Πολιορκητικά), which was dedicated to Hadrian.