Argegno is a comune (municipality) in the Province of Como in the Italian region Lombardy, located about 50 km north of Milan and about 15 km north of Como. As of 31 December 2004, it had a population of 650 and an area of 4.3 km².

The village, like many in the Lake Como area is popular with expatriates, particularly from the United Kingdom, a situation exacerbated by the economic flux in recent years. Indeed the local economy is heavily dependent upon tourism and the service industry.

Argegno is situated on an inlet in the lake, and is built alongside the River Telo which flows into the Lake, the discharge of which is heavily dependent upon the season.

Argegno borders the following municipalities: Brienno, Colonno, Dizzasco, Lezzeno, Nesso, Pigra, Schignano. It is situated in between the villages of Menaggio and Cernobbio.

Argegno is of Roman origin, and is named after the Roman consul Publio Cesio Archigene. With the fall of Rome and the subsequent geopolitical instability in Italy a series of fortifications were constructed in the medieval period, including the arched bridge which still stands. The largest structure in the village is the Sanctuary of Sant'Anna, which was constructed in the seventeenth centuries, and contains stucco work from later centuries.