Casas Grandes (Spanish for Great Houses; also known as Paquimé) is the contemporary name given to a pre-Columbian archaeological zone and its central site, located in northwestern Mexico in the modern-day Mexican state of Chihuahua. It is one of the largest and most complex sites in the region. Developed as multi-storied dwellings about 1350 CE after earlier settlement beginning after 1130 CE, the community was abandoned approximately 1450 CE. Regarded as one of the most significant archaeological zones in the northwestern region, Casas Grandes is located in a wide, fertile valley on the Casas Grandes or San Miguel River, 35 miles (56 km) south of Janos and 150 miles (240 km) northwest of the state capital, the city of Chihuahua. The settlement relied on irrigation to support its agriculture. Casas Grandes has been designated a UNESCO World Heritage Site.

The archaeological zone is contained within the eponymous modern municipio (municipality) of Casas Grandes. The valley and region have been inhabited by indigenous groups for thousands of years.