Chambéry Cathedral (Cathédrale Saint-François-de-Sales de Chambéry) is a Roman Catholic cathedral in Chambéry, France, dedicated to Saint François de Sales.

It is the seat of the Archbishopric of Chambéry, Saint-Jean-de-Maurienne and Tarentaise. This was created in 1779 as the Bishopric of Chambéry. After gaining the territories of the Bishopric of Saint-Jean-de-Maurienne and the Archbishopric of Tarentaise in 1801, it was elevated to an archbishopric in 1817. In 1825 Saint-Jean-de-Maurienne and Tarentaise were re-created as independent dioceses; in 1966 they were once again added to the Archdiocese of Chambéry, which in 2002 adopted its present name.

The building dates from the 15th century, when it was constructed as a Franciscan chapel. The site is very swampy and the building is supported by 30,000 poles. It became the cathedral on the creation of the see in 1779. During the French Revolution it was extensively defaced, and the interior was entirely restored in the early 19th century.

It contains the largest ensemble of trompe l'œil painting in Europe (almost 6,000 m²) by the artists Sevesi and Vicario, as well as a maze almost 35 metres long laid down in 1860-70 and relaid in 1989.