The Coral Gables Biltmore Hotel is a luxury hotel in Coral Gables, Florida, United States. It was designed by Schultze and Weaver and was built in 1926 by John McEntee Bowman and George Merrick as part of the Biltmore hotel chain.

The Miami-Biltmore Hotel & Country Club was designated a National Historic Landmark in 1996.

It served as a hospital during World War II and as a VA Hospital and campus of the University of Miami medical school until 1968. It became a hotel again in 1987 managed by the Seaway Hotels Corporation.

There are some reports that claim this hotel to be haunted, most often by the spirit of Thomas Walsh.

When completed, it was the tallest building in Florida, surpassing the Freedom Tower in Downtown Miami. It was surpassed in 1928 by the Dade County Courthouse, also in Downtown Miami.