Cueva de las Manos (Spanish for Cave of the Hands) is a cave or a series of caves located in the province of Santa Cruz, Argentina, 163 km (101 mi) south of the town of Perito Moreno. It is famous (and gets its name) for the paintings of hands. The art in the cave dates from 13,000 to 9,000 years ago. Several waves of people occupied the cave, and early artwork has been carbon-dated to radiocarbon analysis to ca. 9300 BP. The age of the paintings was calculated from the remains of bone-made pipes used for spraying the paint on the wall blocked by the hand.

The site was last inhabited around 700 CE, possibly by ancestors of the Tehuelche people.