Detroit ( /diˈtrɔɪt/) is the largest city in the U.S. state of Michigan, and the seat of Wayne County. It is the major city among the primary cultural, financial, and transportation centers in the Metro Detroit area, a region of 5.2 million people, and serves as a major port on the Detroit River connecting the Great Lakes system to the Saint Lawrence Seaway. It was founded on July 24, 1701, by the French explorer, adventurer, and nobleman Antoine de la Mothe, sieur de Cadillac.