Firenze Santa Maria Novella (in English Florence Santa Maria Novella) or Stazione di Santa Maria Novella - Firenze SMN is the main national and international railway station in Florence, Italy. The station is used by 59 million people every year and is one of the busiest in Italy.

It is at the northern end of the Florence–Rome direttissima, which was completed on 26 May 1992 and the southern end of the Bologna–Florence Direttissima, opened on 22 April 1934. A new high speed line to Bologna opened on 13 December 2009. The station is also used by regional trains on lines connecting to Pisa, Livorno, Lucca, Viareggio, Bologna and Faenza.