The Gotthard Pass or St. Gotthard Pass (Italian: Passo del San Gottardo) (el. 2106 m) is a high mountain pass in Switzerland between Airolo in the canton of Ticino, and Göschenen in the canton of Uri, connecting the northern German-speaking part of Switzerland with the Italian-speaking part, along the route onwards to Milan.

Though the pass was locally known in antiquity, it was not generally used until the early 13th century because it involved fording the turbulent Reuss, swollen with snowmelt during the early summer, in the narrow steep-sided Schöllenen Gorge (the Schöllenenschlucht), below Andermatt. As early as 1236, it was dedicated to the Bavarian Saint Gotthard of Hildesheim.