Guayaquil (pronounced: [ɡwaʝaˈkil]), officially Santiago de Guayaquil (pronounced: [sanˈtjaɣo ðe ɣwaʝaˈkil]), is the largest and the most populous city in Ecuador, with around 3.8 million residents in the city and nearly 4.1 million in the metropolitan area, as well as the nation's main port. The city is the capital of the Ecuadorian province of Guayas and the seat of the namesake canton.

Guayaquil is located on the western bank of the Guayas River, which flows into the Pacific Ocean at the Gulf of Guayaquil. Because of its location, the city is the center of Ecuador's business and manufacturing industries.