The Hôtel de Soubise (pronounced: [otɛl də subiːz]) is a city mansion entre cour et jardin ([ɑ̃ːtʁ kuːʁ e ʒaʁdɛ̃]), located at 60 rue des Francs-Bourgeois, in the IIIe arrondissement of Paris.

The Hôtel de Soubise was built for the Prince and Princess de Soubise on the site of a semi-fortified manor house named the Grand-Chantier built in 1375 for connétable Olivier de Clisson, that had formerly been a property of the Templars. The site previously contained the Hôtel de Guise, the Paris residence of the Dukes of Guise, a cadet branch of the House of Lorraine. It was the birth place of the last Duke, Francis Joseph, Duke of Guise, the son of Élisabeth Marguerite d'Orléans, Duchess of Alençon. He died in 1675 and the Guise estate passed to Marie de Lorraine who died at the Hôtel in 1688 having been born there in 1615.