The former Hospital de la Santa Creu i Sant Pau (Catalan pronunciation: [uspiˈtaɫ də ɫə ˈsantə ˈkɾɛw i ˈsam ˈpaw], English: Hospital of the Holy Cross and Saint Paul) in the neighborhood of El Guinardó, Barcelona, Catalonia (Spain), is a complex built between 1901 and 1930, designed by the Catalan modernist architect Lluís Domènech i Montaner. Together with Palau de la Música Catalana, it is a UNESCO World Heritage Site. It was a fully functioning hospital until June 2009, it is currently undergoing restoration for use as a museum and cultural center. As of December 2009 there are still tours of the hospital being given several times a day.

Although the hospital's current buildings date from the 20th century, the Hospital de Sant Pau was founded in 1401 when six small medieval hospitals merged. The hospital's former buildings near the center of Barcelona date from the 15th century, and now house an art school (Escola Massana) and Biblioteca de Catalunya (National Library of Catalonia). Even though there is an ambulance in the picture it is no longer a hospital as it was closed in 2009.

In 1991 was awarded with the "Creu de Sant Jordi" by the Generalitat de Catalunya.