The khene (/ˈkɛn/; also spelled "khaen", "kaen" and "khen"; Lao: ແຄນ; Thai: แคน, RTGS: khaen, pronounced [kʰɛ̄ːn]; Khmer: គែន) is a mouth organ of Lao origin whose pipes, which are usually made of bamboo, are connected with a small, hollowed-out hardwood reservoir into which air is blown, creating a sound similar to that of the violin. Today associated with the Lao of Laos and Northeast Thailand, similar instruments date back to the Bronze Age of Southeast Asia. In Cambodia, it is used among the ethnic Lao population of the province of Stung Treng and is used in lakhon ken, a Cambodian dance drama genre that features the khene as the premiere instrument.

The most interesting characteristic of the khene is its free reed, which is made of brass or silver. It is related to Western free-reed instruments such as the harmonium, concertina, accordion, harmonica, and bandoneon, which were developed beginning in the 18th century from the Chinese sheng, a related instrument, a specimen of which had been carried to St. Petersburg, Russia.