Lisboa e Vale do Tejo (Portuguese pronunciation: [liʒˈboɨ i vaɫ du ˈtɛʒu]; English: Lisbon and Tagus Valley) was one of the five Regions of Portugal (NUTS II subdivisions). Today two of the subregions are in the new Lisboa Region, two in the Centro Region and one in the Alentejo Region.

The region still exists as the area of intervention of the CDDR planning region.

It had 3,447,173 inhabitants (2001), and its area was 11,930 km².