Mandalay Bay Resort and Casino is a 44-story luxury hotel casino on the Las Vegas Strip in Paradise, Nevada. It is owned by MGM Resorts International. Five floors (floors 35–39) of the main hotel building are occupied by the five-star and AAA Five-Diamond Four Seasons Hotel Las Vegas. The top 3 floors (numbered as floors 60-62) are penthouses, with a penthouse lounge on level 62 for guests staying in the penthouses. It is connected by the free Mandalay Bay Tram to its sister properties, Excalibur and Luxor.

Mandalay Bay has 3,309 hotel rooms, 24 elevators and a casino of 135,000 sq ft (12,500 m²). The adjacent Mandalay Bay Convention Center has almost 1,000,000 sq ft (93,000 m²) of space. In addition, the Mandalay Bay Events Center hosts events including boxing, the UFC's MMA fights and concerts. It hosted the Latin Grammy Awards in 2007 and from 2009 to 2011. It will host the Latin Grammys again in 2012.