Mandalay Region (Burmese: မန္တလေးတိုင်းဒေသကြီး, pronounced: [máɴdəlé táiɴ dèθa̰ dʑí], formerly Mandalay Division) is an administrative division of Myanmar. It is located in the center of the country, bordering Sagaing Region and Magway Region to the west, Shan State to the east, and Bago Region and Kayin State to the south. The regional capital is Mandalay. In the south of the division lies the national capital of Naypyidaw. The division consists of seven districts, which are subdivided into 30 townships and 2,320 wards and village-tracts.

Mandalay Region is important in Burma's economy, accounting for 15% of the national economy.