Mesoamerican architecture is the set of architectural traditions produced by pre-Columbian cultures and civilizations of Mesoamerica, traditions which are best known in the form of public, ceremonial and urban monumental buildings and structures. The distinctive features of Mesoamerican architecture encompass a number of different regional and historical styles, which however are significantly interrelated. These styles developed throughout the different phases of Mesoamerican history as a result of the intensive cultural exchange between the different cultures of the Mesoamerican culture area through thousands of years. Mesoamerican architecture is mostly noted for its pyramids which are the largest such structures (outside of Ancient Egypt and the Chola Empire).

One interesting and widely researched topic is the relation between cosmovision, religion, geography, and architecture in Mesoamerica. Much seems to suggest that many traits of Mesoamerican architecture were governed by religious and mythological ideas. For example, the layout of most Mesoamerican cities seem to be influenced by the cardinal directions and their mythological and symbolic meanings in Mesoamerican culture.

Another part of Mesoamerican architecture is its iconography. The monumental architecture of Mesoamerica was decorated with images of religious and cultural significance, and also in many cases with writing in some of the Mesoamerican writing systems. Iconographic decorations and texts on buildings are important contributors to the overall current knowledge of pre-Columbian Mesoamerican society, history and religion.