Mesopotamia (from the Greek: Μεσοποταμία: "[land] between rivers"; Arabic: بلاد الرافدين‎ (bilād al-rāfidayn); Syriac: ܒܝܬ ܢܗܪܝܢ (beth nahrain): "land of rivers") is a toponym for the area of the Tigris–Euphrates river system, largely corresponding to modern-day Iraq, northeastern Syria, southeastern Turkey and southwestern Iran.

Widely considered to be the cradle of civilization, Bronze Age Mesopotamia included Sumer and the Akkadian, Babylonian and Assyrian empires. In the Iron Age, it was controlled by the Neo-Assyrian and Neo-Babylonian empires. The indigenous Sumerians and Akkadians (including Assyrians and Babylonians) dominated Mesopotamia from the beginning of written history (c. 3100 BC) to the fall of Babylon in 539 BC, when it was conquered by the Achaemenid Empire. It fell to Alexander the Great in 332 BC and, after his death, it became part of the Greek Seleucid Empire.