Mestre is the center and the most populated urban area of the mainland of Venice, part of the territory of the city of Venice, in Veneto, northern Italy.

Administratively speaking, Mestre forms (together with the nearby urban area of Carpenedo) the Municipalità di Mestre-Carpenedo, one of the six boroughs of the commune (Comune) of Venice. Sometimes considered as frazione, it is the most populated one of Italy, counting around 170,000 inhabitants.