Nishi-Shinjuku (西新宿^?) is a skyscraper business district in Shinjuku, Tokyo, Japan. This region was called Tsunohazu (角筈^?) before.

Nishi-Shinjuku was Tokyo's first major foray into building skyscrapers with the first appearing in the 1970s with Keio Plaza Inter-Continental. Kenzo Tange's Tokyo Metropolitan Government Building being the current latest. Tower I was also the tallest building in Japan at this time.

Progress continues in Nishi-Shinjuku and in West Shinjuku which is heading away from the city center and has the site of the proposed Nishi-Shinjuku 3-Chōme Redevelopment with plans for what will be three of the four tallest buildings in Japan.