Oṃ maṇi padme hūṃ (Sanskrit: ओं मणिपद्मे हूं, IPA: [õːː məɳipəd̪meː ɦũː]) is the six syllabled mantra particularly associated with the four-armed Shadakshari form of Avalokiteshvara (Tibetan Chenrezig, Chinese Guanyin), the bodhisattva of compassion. Mani means "the jewel" and Padma means "the lotus".

The mantra is especially revered by devotees of the Dalai Lama, as he is said to be an incarnation of Chenrezig or Avalokiteshvara.

It is commonly carved onto rocks or written on paper which is inserted into prayer wheels, said to increase the mantra's effects.