Ossuccio is a comune (municipality) in the Province of Como in the Italian region Lombardy. It is located on the western shore of Lake Como some 20 km northeast of Como. As of 31 December 2004, it had a population of 975 and an area of 8.0 km².

It is known for the Sacro Monte, a site of pilgrimage and worship close to it, for the late 16th century Villa del Balbiano[1], the mid-20th century Villa Leoni[2], and for the island of Comacina which falls within its territory.

Ossuccio borders the following municipalities: Colonno, Lenno, Lezzeno, Ponna, Porlezza, Sala Comacina.