Despite the presence of famous cultivations of lemons (the meaning of the city's name in Italian), the town's name is probably derived from the ancient lemos (elm) or limes (Latin: boundary, referring to the communes of Brescia and the Bishopric of Trento). In 1863-1905 the denomination was Limone San Giovanni.
Until the 1940s the city was reachable only by lake or through the mountains, with the road to Riva del Garda being built only 1932, but today Limone is one of the most renowned tourist resorts in the area.
In 1979 researchers discovered that people in Limone possess a mutant form of apolipoprotein (called ApoA-1 Milano) in their blood, that induced a healthy form of high-density cholesterol, which resulted in a lowered risk of atherosclerosis and other cardiovascular diseases.
The protein has given residents of the village extreme longevity - a dozen of those living here are over the age of 100 (for c. 1,000 total inhabitants). The origin of the mutation has been traced back to a couple who lived in Limone in the 17th century.