The Reserva Provincial La Payunia (Spanish: La Payunia Provincial Reserve) also known as Payún or Payén is a natural reserve located in the Malargüe Department in the southern part of Mendoza Province, Argentina, about 160 km away from Malargüe city. It was declared as nature preserve in 1988 and has an area of 4,500 km². La Payunia is home to the many volcanic cones, being noteworthy the Payún Matrú volcano.