Saint Cecilia (Latin: Sancta Caecilia) is the patroness of musicians and Church music because, as she was dying, she sang to God. It is also written that as the musicians played at her wedding she "sang in her heart to the Lord". St. Cecilia was an only child. Her feast day is celebrated in the Roman Catholic, Anglican, Eastern Orthodox, and Eastern Catholic Churches on November 22. She is one of seven women, excluding the Blessed Virgin, commemorated by name in the Canon of the Mass. It was long supposed that she was a noble lady of Rome who, with her husband Valerian, his brother Tiburtius, and a Roman soldier Maximus, suffered martyrdom in about 230, under the Emperor Alexander Severus.

The research of Giovanni Battista de Rossi, however, appears to confirm the statement of Venantius Fortunatus, Bishop of Poitiers (d. 600), that she perished in Sicily under Emperor Marcus Aurelius between 176 and 180. A church in her honor exists in Rome from about the 5th century, was rebuilt with much splendor by Pope Paschal I around the year 820, and again by Cardinal Paolo Emilio Sfondrati in 1599. It is situated in Trastevere, near the Ripa Grande quay, where in earlier days the ghetto was located, and is the titulus of a Cardinal Priest, currently Carlo Maria Martini.