San Ignacio Miní was one of the many missions founded in 1632 by the Jesuits in the Americas during the Spanish colonial period near present-day San Ignacio valley, some 60km north of Posadas, Misiones Province, Argentina.

The original mission was erected near the year 1610 by priests José Cataldino and Simón Maceta in the region called Guayrá by the natives and La Pinería by the Spanish conquistadores in present Paraná State, Brazil. Because of the constant attacks of the Portuguese Bandeirantes, the mission first moved in 1632, and didn't settle in its current location until 1696, and was called San Ignacio Miní (minor in Guaraní) to distinguish it from its bigger homonym San Ignacio Guazú (great).

In the 18th century the mission had a population of around 3000 people, and a rich cultural and handicraft activity, which was commercialized through the nearby Paraná River. Nevertheless, after the Suppression of the Society of Jesus of 1767, the Jesuits left the mission a year later, and the mission finally destroyed in 1817, as well as other missions in the area.