Santa Maria in Via Lata is a church on the Via del Corso (the ancient Via Lata), in Rome, Italy.

It is claimed that St. Paul spent two years here, in the crypt under the church, whilst under house arrest waiting for his trial. This conflicts with the tradition regarding San Paolo alla Regola. The same was also claimed for St Peter, Paul's secretary Luke, Peter's disciple Martial, St John.

The first Christian place of worship here was a 5th century oratory (chapel with welfare centre) in the Roman building beneath the present church. This was constructed within the remains of a large Roman warehouse, some 250 metres long, which has also been excavated. The church's upper level was added in the 9th century, and murals added to the lower level between the 7th and 9th centuries (these have been detached for conservation reasons). The cosmatesque pavement from this phase survives.

The church's 13th century icon of the Virgin Advocate, said to have performed many miracles, and relics of the 3rd century Deacon and martyr Agapitus lie beneath it. The Arcus Novus (an arch erected by emperor Diocletian in 303-304), which stood on this site were destroyed for a rebuild of the church in the late 15th century, c. 1491. Antonio Tebaldeo, poet and friend of Raphael, was buried at the end of the north aisle in 1537, though his tomb was designed in 1776.