Sikandar Lodi (died November 21, 1517), born Nizam Khan, was the second ruler of the Afghan Lodi Dynasty, who reigned over Sultanate of Delhi from 1489 to 1517.

Sikandar Lodi was the son of Sultan Bahlul Khan Lodi and Bibi Ambha, the daughter of a Hindu goldsmith of Sirhind.

He became Sultan upon the death of his father on July 17, 1489. His rise to power was troublesome, with his older brother, Barbak Shah, the viceroy of Jaunpur, also staking a claim to the throne despite their father's nomination of Sikandar. However, he was able to claim the throne through delegation and was able to avoid massive bloodshed. In fact, he allowed his brother to keep governing Jaunpur, while also settling differences with an uncle, Alam Khan, who was also suspected of usurping the throne. Sikandar proved to be a capable ruler who was kind to his Muslim subjects, but was extremely harsh to his Hindu subjects. He expanded Lodi territory into the regions of Gwalior and Bihar. He made a treaty with Alauddin Hussain Shah and his kingdom of Bengal. He was able to bring his native Afghan nobles under his control, and encouraged trade across his holdings. In 1503, he commissioned the building of the present-day city of Agra.