The Speyer Cathedral, officially the Imperial Cathedral Basilica of the Assumption and St Stephen, in Latin: Domus sanctae Mariae Spirae (German: Dom zu Unserer lieben Frau in Speyer) in Speyer, Germany, is the seat of the Roman Catholic Bishop of Speyer and is suffragan to the Archdiocese of Bamberg. The cathedral, which is dedicated to St. Mary, patron saint of Speyer ("Patrona Spirensis") and St. Stephen is generally known as Kaiserdom zu Speyer (Imperial Cathedral of Speyer). Pope Pius XI raised Speyer Cathedral to the rank of a minor basilica of the Roman Catholic Church in 1925.

Begun in 1030 under Conrad II, the imposing triple-aisled vaulted basilica of red sandstone is the "culmination of a design which was extremely influential in the subsequent development of Romanesque architecture during the 11th and 12th centuries". As the burial site for Salian, Staufer and Habsburg emperors and kings the cathedral is regarded as a symbol of imperial power. With the Abbey of Cluny in ruins, it remains the largest Romanesque church. It is considered to be "a turning point in European architecture", one of the most important architectural monuments of its time and one of the finest Romanesque monuments.