Valle de los Ingenios, Valley de los Ingenios or Valley of the Sugar Mills is a series of three interconnected valleys about 12 kilometres (7.5 mi) outside of Trinidad, Cuba. The three valleys, San Luis, Santa Rosa and Meyer, were a centre for sugar production from the late 18th century until the late 19th century. At the peak of the industry in Cuba there were over fifty cane sugar mills in operation in the three valleys with over 30,000 slaves working in the mills and the sugar cane plantations that surrounded them. The entire area covers 270 km² (100 sq mi) and includes the sites of over 70 former sugar mills.

Sugar production was an important industry for Cuba from the earliest settlement by the Spanish, who introduced sugar cane to the island in 1512, and trade in the commodity enriched Trinidad and the surrounding areas. The island became the world's foremost producer of sugar during the late 18th and 19th centuries, when sugar production was the main industry. The climate and soil were perfect for the cultivation of sugar cane, and good ports and interior connections facilitated transport and exportation of the refined sugar. To prevent the sugar from spoiling rapid transport was necessary, and to this end a special railway line was laid down through the valley in the late 1880s, connecting the Valle de los Ingenios with Trinidad and the port at Casilda, 6 km (4 mi) from Trinidad, on the coast. The valleys are provided with water by several rivers, among them Rio Agabama, Rio Caracusey, Rio de Ay, and Rio Tayaba. Due to the virtual extinction of the native Cubans through contact with diseases brought by the European settlers and attrition though their poor treatment as slaves, it was necessary for the Spanish plantation owners to import slaves from Africa to work in the sugar cane fields and in the mills. The abolition of slavery by the Spanish in 1820 made the practice of importing slaves more difficult, but it was not until the Wars of Independence in the 19th century that the dominance of the area came to an end, as many of the sugar mills were abandoned or became run down.