The Valley of Mexico is a highlands plateau in central Mexico roughly coterminous with the present-day Distrito Federal and the eastern half of the State of Mexico. Surrounded by mountains and volcanoes, the Valley of Mexico was a centre for several pre-Columbian civilizations, including Teotihuacan, the Toltec, and the Aztec. The ancient Aztec term Anahuac (Land Between the Waters) and the phrase Basin of Mexico are both used at times to refer to the Valley of Mexico. The Basin of Mexico became a well known site that epitomized the scene of early Classic Mesoamerican cultural development as well.

The Valley of Mexico is located in the Trans-Mexican Volcanic Belt. The valley contains most of the Mexico City Metropolitan Area, as well as parts of the State of Mexico, Hidalgo, Tlaxcala and Puebla. The Valley of Mexico can be subdivided into four basins, but the largest and most-studied is the area which contains Mexico City. This section of the valley in particular is colloquially referred to as the "Valley of Mexico". The valley has a minimum altitude of 2,200 metres (7,200 ft) above sea level and is surrounded by mountains and volcanoes that reach elevations of over 5,000 metres (16,000 ft). It is an enclosed valley with no natural outlet for water to flow and a gap to the north where there is a high mesa but no high mountain peaks. Hydrologically, the valley has three features. The first feature is the lakebeds of five now-extinct lakes, which are located in the southernmost and largest of the four sub-basins. The other two features are piedmont, and the mountainsides that collect the precipitation that eventually flows to the lake area. These last two are found in all four of the sub-basins of the valley. Seismic activity is frequent here, and the valley is considered an earthquake prone zone.