The V Valparaíso Region (Spanish: V Región de Valparaíso) is one of Chile's 15 first order administrative divisions. With the country's third highest population of 1,539,852 million in 2002 and third smallest area of 16,396.1 km² (6,331 sq mi), the region is Chile's second most densely populated after the Santiago Metropolitan Region to the southeast.

Its capital is the port city of Valparaíso, other important cities include Viña del Mar, Quillota, Quilpué and Villa Alemana.