Venezia Santa Lucia railway station (Italian: Stazione di Venezia Santa Lucia) is a terminal station serving the comune of Venice, Italy. It is also the only railway station in the historic city of Venice (Italian: Centro storico).

The station is one of Venice's two most important railway stations, the other one being Venezia Mestre, a junction station in Venice's mainland frazione of Mestre. Both stations are managed by Grandi Stazioni, and they are linked with each other by the Ponte della Libertà (English: Liberty Bridge) between the mainland and the historic city.